3D-PRINTED FLEXIBLE NEURAL PROBES FOR RECORDINGS AT SINGLENEURON LEVEL
Research Poster Engineering 2025 Graduate ExhibitionPresentation by Marzia Momin
Exhibition Number 9
Abstract
Neural recording technologies offer valuable insights into neural activities that can help develop treatments for a wide range of conditions involving the brain, spinal cord, and other nervous systems. However, mismatches in material properties between these often-rigid electronic devices and biological neural tissues can lead to problems in biocompatibility (e.g., causing inflammation) and stability (e.g., dislocating contact). Here, we present a 3D-printable, flexible, stretchable electronic device with a porous, tissue-like structure designed for neural recording. This porous configuration bestows flexibility, stretchability, and conformability alongside chemical permeability, enabling integration with the brain and spinal cord. The 3D printability offers customization, cost efficiency, and scalability. The prototype device exhibits reduced impedance compared to conventional metal- or silicon-based devices, facilitating their precision in capturing neural activities at the cellular level in both the brain and spinal cord. The design lays a foundation for future research in brain-computer interfaces, neuromodulation, and neural prosthetics.
Importance
Our customized soft, porous, and 3D printable neural probe offers adaptability for multi-module devices, integrating advanced chemical sensing technologies for sophisticated neural interfaces capable of higher resolution such as cellular-level sensing and recordings. Its design facilitates neurotransmitter exchange, enabling the study of neural processes in their natural environment, and may have applications in therapeutic interventions and as diagnostic tools. Innovations, especially in conductive 3D-printable materials, can be incorporated into neural device manufacturing methodology for enhanced performance, establishing a platform for next-generation neural probes tailored to neural electronics needs.
DEI Statement
As a woman originally from Bangladesh, an underdeveloped country with limited representation of women in engineering, particularly in neuroengineering, my journey reflects a commitment to diversity, equity, and inclusion. I strive to inspire others by pursuing advanced research in neural implant technologies. My work emphasizes personalized solutions for neurological disorders, addressing global health disparities by ensuring affordability and accessibility. Beyond research, I actively mentor young women, exemplified by my volunteer experience at Envision: STEM Career Day Supporting Young Women, inspiring them to overcome barriers in STEM. By advocating for equitable opportunities and inclusion in academia and industry, I aim to pave the way for more women, particularly from underserved communities, to excel in STEM and contribute to transformative global innovations.